Altered “Ribostasis”: RNA-protein granule formation or persistence in the development of degenerative disorders
نویسندگان
چکیده
1School of Genetics and Microbiology and School of Natural Sciences, Smurfit Institute of Genetics and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin-2 Ireland 2Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN 38120 USA 3Department of Biochemistry and Chemistry, and the Howard Hughes Medical Institute, University of Colorado, Boulder CO, USA
منابع مشابه
Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders
The molecular processes that contribute to degenerative diseases are not well understood. Recent observations suggest that some degenerative diseases are promoted by the accumulation of nuclear or cytoplasmic RNA-protein (RNP) aggregates, which can be related to endogenous RNP granules. RNP aggregates arise commonly in degenerative diseases because RNA-binding proteins commonly self-assemble, i...
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